ESOcast 45 -- Reaching Out -- is the fifth special episode of this series. In it we focus on ESO's mission of curiosity, wonder and inspiration, proclaimed through cooperation and outreach. Indeed, cooperation has always been the basis for ESO's success, ever since the organisation was founded fifty years ago. Together, ESO's Member States enable the best possible astronomical science at the world's largest observatories. ESO also works closely with industry, universities and research institutes around the world in developing state-of-the-art technologies. Furthermore, through engagement with the public, ESO provides countless ways to participate in the discovery of the cosmos, inviting everyone to join this exciting adventure.