At a fundamental level, what is our Universe made of? This question has driven physics forward for centuries. Even with all the advances we’ve made, we still don’t know it all. While the Large Hadron Collider discovered the Higgs boson and completed the Standard Model earlier this decade, the full suite of the particles we know of only make up 5% of the total energy in the Universe.
We don’t know what dark matter is, but the indirect evidence for it is overwhelming. Same deal with dark energy. Or questions like why the fundamental particles have the masses they do, or why neutrinos aren’t massless, or why our Universe is made of matter and not antimatter. Our current tools and searches have not answered these great existential puzzles of modern physics. Particle physics now faces an incredible dilemma: try harder, or give up.